The Yeti airline ATR-72 crashed in Pokhara around 11 am Sunday.
At least 32 people died as the aircraft crashed few KM away from the destination.
The aircraft took off at 10:33 am from Kathmandu to Pokhara with 72 people on board including crew members.
Yeti Airlines spokesman Suman Bartaula said that two pilots, two air hostesses and 68 passengers were on board the ill-fated plane.
The hospital and ambulances have been alerted after information was received that a plane has crashed in the Seti river gorge, according to Tek Bahadur KC, Chief District officer of Kaski.